Danny Phantom (David Kaufman) is the primary main character of the series. Originally, he started off as a shy, average, clumsy, and occasionally superficial 14-year-old boy who was desperate to fit in with his peers and be accepted. After a lab accident in his parents' ghost hunting lab he became a half-ghost, and obtains a variety of ghostly abilities. A battle with a Lunch Lady Ghost placed the unsure Danny on the path to becoming a hero. Despite his flaws, he is steadfast and loyal to his friends and family, He eventually grows, gaining great confidence and maturity within in himself, concentrating more on his heroic duties.

He is constantly under persuasion from his rival and arch nemesis, Vlad Masters whom wants him as his son and apprentice.

Danny is unsure of his feelings for Samantha "Sam" Manson unsure if what he feels about her is more than is shown.Though throughout the series his feelings have slipped out in small doses, neither Danny or Sam confess their feelings for each other until Phantom Planet.